Table of contents
- 1. Intro to Stats and Collecting Data55m
- 2. Describing Data with Tables and Graphs1h 55m
- 3. Describing Data Numerically1h 45m
- 4. Probability2h 16m
- 5. Binomial Distribution & Discrete Random Variables2h 33m
- 6. Normal Distribution and Continuous Random Variables1h 38m
- 7. Sampling Distributions & Confidence Intervals: Mean1h 3m
- 8. Sampling Distributions & Confidence Intervals: Proportion1h 12m
- 9. Hypothesis Testing for One Sample1h 1m
- 10. Hypothesis Testing for Two Samples2h 8m
- 11. Correlation48m
- 12. Regression1h 4m
- 13. Chi-Square Tests & Goodness of Fit1h 20m
- 14. ANOVA1h 0m
4. Probability
Basic Concepts of Probability
Problem 4.1.28c
Textbook Question
In Exercises 21-28, find the probability and answer the questions.
X-Linked Genetic Disease Men have XY (or YX) chromosomes and women have XX chromosomes. X-linked recessive genetic diseases (such as juvenile retinoschisis) occur when there is a defective X chromosome that occurs without a paired X chromosome that is not defective. In the following, represent a defective X chromosome with lowercase x, so a child with the xY or Yx pair of chromosomes will have the disease and a child with XX or XY or YX or xX or Xx will not have the disease. Each parent contributes one of the chromosomes to the child.
c. If a mother has one defective x chromosome and one good X chromosome and the father has good XY chromosomes, what is the probability that a son will inherit the disease?

1
Step 1: Understand the genetic inheritance. The mother has one defective x chromosome (x) and one good X chromosome (X), while the father has good XY chromosomes. Sons inherit one X chromosome from their mother and one Y chromosome from their father.
Step 2: List all possible combinations of chromosomes for a son. Since the son inherits the Y chromosome from the father, the possible combinations for the son are xY (defective X from the mother) or XY (good X from the mother).
Step 3: Determine the probability of each combination. The mother has a 50% chance of passing on the defective x chromosome and a 50% chance of passing on the good X chromosome. The father always contributes the Y chromosome.
Step 4: Identify the condition for the son to inherit the disease. The son will inherit the disease if he has the xY chromosome pair, which occurs when the mother passes on the defective x chromosome.
Step 5: Calculate the probability. Since the mother has a 50% chance of passing on the defective x chromosome, the probability that the son will inherit the disease is 50% or 0.5.

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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
X-Linked Inheritance
X-linked inheritance refers to the pattern of genetic transmission of traits or diseases that are associated with genes located on the X chromosome. In this case, males (XY) are more likely to express X-linked recessive diseases because they have only one X chromosome. If the X chromosome inherited from the mother carries a recessive allele for a disease, the son will express that disease since he does not have a second X chromosome to mask the effect.
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Probability in Genetics
Probability in genetics involves calculating the likelihood of inheriting specific traits based on the genetic makeup of the parents. In this scenario, the probability of a son inheriting the disease can be determined by analyzing the combinations of chromosomes contributed by each parent. The mother, with one defective X chromosome, has a 50% chance of passing on either her defective or normal X chromosome to her son.
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Punnett Square
A Punnett square is a diagram used to predict the genetic outcomes of a cross between two parents. It helps visualize the possible combinations of alleles that offspring may inherit. In this case, constructing a Punnett square with the mother's X chromosomes (X and x) and the father's XY chromosomes will clarify the probability of the son inheriting the defective X chromosome and thus the disease.
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